Welcome to The Times in Plain English   Click to listen highlighted text! Welcome to The Times in Plain English

Men and Women Have Different Reactions to Drugs

February 2, 2013
Plain English Version

Studies of sleeping pills show that men and women need different doses to get the same result. For example, the Food and Drug Administration (F.D.A.) recommends that women take 1.75 milligrams of the sleeping drug Intermezzo versus 3.5 milligrams for men.

Research is showing that men and women metabolize drugs, including aspirin, in different ways. A scientist said, “There are a lot of sex differences for a lot of drugs, some of which are well-known and some that are not.”

One reason we now are learning more is that women used to be left out of trials of new drugs. In 1993, the ban on testing women of childbearing age was lifted. Studies now show that women also react differently to alcohol, tobacco and cocaine.

It is not just because of their size. Women have a higher percentage of body fat, hormonal changes and a menstrual cycle. These differences affect how the body handles drugs.

There are also sex differences in liver and kidney function and certain gastric enzymes. Oral contraceptive, menopause and later hormone treatment also produce different drug effects.

Researchers say more women are needed in clinical trials. They note that women are not used as much as they should be in heart, kidney and even cancer trials.

The New York Times

Print Friendly

Features

Migraine Headaches: Go Away!

Many suffer from migraine headaches. One wrote:

If you’ve never had a migraine, I have two things...

Next Global Challenges: Heart Diseases and Epidemics

Big money may be able to make big things happen. The Bloomberg, Gates and Zuckerberg foundations are getting together. They...

Do Not Argue. Get Some Sleep.

There is an old song that goes:

“Lucky, lucky, lucky me, I’m a lucky son of a...

More People Are Allergic to Peanuts, Why?

No one knows for sure how many people are allergic. Scientists only know that the number is growing at a...

Archives

Dictionary
  • dictionary
  • English Dictionary

Double click on any word on the page or type a word:

Powered by dictionarist.com
Click to listen highlighted text!